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  Principal Investigator

Youdong Mao (毛有东), Ph.D.

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Principal Investigator
Institute of Condensed Matter and Material Physics, School of Physics
Center for Quantitative Biology

Phone: +86-10-62750295
E-mail: ymao_at_pku.edu.cn
Mailing Address:
Physics Building, Room Middle-324
Peking University
5 Yiheyuan Road, Haidian District
Beijing 100871, China

Recent Publications

  1. Dong Y, Zhang S, Wu Z, Li X, Wang WL, Zhu Y, Stoilova-McPhie S, Lu Y, Finley D, Mao Y*. Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome. Nature 565, 49-55 (2019). doi: 10.1038/s41586-018-0736-4.

  2. Dong Y, Chen S, Zhang S, Sodroski J, Yang Z, Liu D, Mao Y*. Folding DNA into a lipid-conjugated nanobarrel for controlled reconstitution of membrane proteins. Angew. Chem. Int. Ed. 57, 2072-2076 (2018). doi:10.1002/anie.201710147.

  3. Lu Y, Wu J, Dong Y, Chen S, Sun S, Ma YB, Ouyang Q, Finley D, Kirschner MW*, Mao Y*. Conformational landscape of the p28-bound human proteasome regulatory particle. Mol. Cell 67, 322-333.e6 (2017). doi: 10.1016/j.molcel.2017.06.007.

  4. Wu J, Ma Y, Congdon C, Brett B, Chen S, Ouyang Q, Mao Y*. Massively parallel unsupervised single-particle cryo-EM data clustering via statistical manifold learning. PLoS ONE 12, e0182130 (2017). doi: 10.1371/journal.pone.0182130.

  5. Zhang L, Chen S, Ruan J, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y*, Wu H*. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350, 404-409 (2015). doi: 10.1126/science.aac5789.